Kalyana Parisu tells the story of Gayathri, Subbulakshmi, and Renuka — three women whose lives become intertwined with love, sacrifice, and betrayal. When Surya marries both Subbulakshmi and Gayathri under unforeseen circumstances, their friendships and families are thrown into turmoil. The series explores the themes of loyalty, love, revenge, and resilience across generations.